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KMID : 1059520080520060657
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Journal of the Korean Chemical Society
2008 Volume.52 No. 6 p.657 ~ p.662
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Synthesis and Antimicrobial Activity of Dimethyl (2-cyanophenylamino) (Substituted Aryl) Methyl Phosphonates
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Reddy G. Chandra Sekhar
Kumar B. Siva
Sankar A. Uma Ravi
Reddy M. Veera Narayana
Reddy C. Suresh
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Abstract
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A new class of α-aminophosphonic acid esters (4a-l) have been synthesized by three component one-pot reaction with equimolar quantities of 2-amino benzonitrile (1), dimethylphosphite (3) and various aldehydes (2a-l) in dry toluene at reflux conditions via Kabachnic-Fields reaction in high yields (74-85%).The structure of title compounds has been established by elemental, IR, 1H, 13C, 31P and Mass spectral analysis. They were found to possess significant antimicrobial activity.
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KEYWORD
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2-amino Benzonitrile, Dimethylphosphite, Kabachnic-Fields Reaction, α-aminophosphonic Acid Esters, Antimicrobial Activity
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